ACI Medication Administration Practice Test 2025 – Complete Prep Guide

Nitroglycerin tablets are commonly administered by placing them under the tongue to allow for sublingual absorption. This method is effective because the medication can enter the bloodstream quickly through the rich network of blood vessels in the area beneath the tongue. This allows for rapid relief of angina symptoms since nitroglycerin works by dilating blood vessels and increasing blood flow to the heart.

The sublingual route bypasses the digestive system and avoids first-pass metabolism in the liver, which enhances the onset of action of the medication. This is particularly important in emergency situations where a swift response to chest pain is necessary. Other administration methods, such as taking the tablets with water or dissolving them under the skin, are not appropriate for nitroglycerin and would not ensure the intended rapid therapeutic effect. Placing the tablets between the cheek and gums does not offer the same efficacy for absorption and speed of action as the sublingual route does.